as a long time drug addict I can not take anything. I mean even if it did not give me a high. just a deadness would do as long as it was something ya know. Venlafaxine and Alcohol. Do not drink alcohol while taking venlafaxine, as alcohol can augment the sleepiness effect of the drug. Venlafaxine and Other Interactions What other drugs will affect Effexor? Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking Effexor with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures. Call your doctor immediately if you have severe pain at any time while taking Boniva. Boniva may also raise the risk of breaking your thigh bone. Before taking ketorolac, tell your doctor if you are taking pentoxifylline (Pentoxil) or probenecid (Probalan, in Col-Probenecid). Your doctor will probably tell you not to take ketorolac if you are taking one or more of these medications. You should not take this medicine if you are allergic to venlafaxine or desvenlafaxine. Do not use venlafaxine within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. What should I discuss with my healthcare provider before taking venlafaxine? You should not take this medicine if you are allergic to venlafaxine or desvenlafaxine. Do not use venlafaxine within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline. Trintellix can cause mild or serious side effects. The following list contains some of the key side effects that may occur while taking Trintellix. People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as naproxen may have a higher risk of having a heart attack or a stroke than people who do not take these medications. Before taking this medicine. You should not take Effexor XR if you are allergic to Effexor XR or desthis medicine. Do not use Effexor XR within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.